Decreased diversity of the fecal Microbiome in recurrent Clostridium difficile-associated diarrhea.

By J. Chang, Dionysios A. Antonopoulos, Apoorv Kalra, A. Tonelli, Walid Khalife, T. Schmidt, Vincent B. Young. Journal of Infectious Diseases, 2008

1,044 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bc6114114645cf46e2e32fcab7ea848847cbaa34

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Citations in the corpus

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut (2013, background): “An association has been made between recurrent disease and intestinal dysbiosis [4], and an inability of certain individuals to reestablish their normal intestinal bacteria is thought to play a leading role in recurrence.”
Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. (2012, background): “Much of the initial research focus on the microbiome has been on understanding disease (Chang et al., 2008; Giongo et al., 2011; Sepehri et al., 2007; Young et al., 2011).”
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. (2012, neutral): “difficile associated diarrhea [40–43].”
16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis (2009, background): “The concept that prolonged antibiotic administration decreases intestinal microbial diversity and predisposes to intestinal disease has been demonstrated for Clostridium difficile colitis, and antibiotic-associated diarrhea (Young and Schmidt, 2004; Chang et al., 2008).”
Gut microbiota in health and disease. (2010, background): “(41), while antibiotic treatment of mice carrying C.”
From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome (2012, background): “Similarly, there is a dearth of empirical data indicating whether people with high or low diversity microbiomes are more prone or resistant to disease, although there is some evidence suggesting that such relationships may exist (Chang et al. 2008, Mazmanian et al. 2008, Packey & Sartor 2009).”
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation (2016, background): “Increased susceptibility to infection and diarrhea [34, 46, 77, 78]”