Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation.

By Y. Taur, João B. Xavier, Lauren Lipuma, C. Ubeda, J. Goldberg, Asia Gobourne, Y. Lee, K. Dubin, Nicholas D. Socci, A. Viale and 4 more. Clinical Infectious Diseases, 2012

929 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a022502320ba1ce49c3c2dc2577b0cfad5740aba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Y. Taur
2. Eric G. Pamer
3. J. Wargo

In Molecular Biology

1. Y. Taur
2. M. Perales
3. M. V. D. van den Brink
4. Rebekah M. Martin
5. Christopher Sander
6. V. Gopalakrishnan
7. João B. Xavier
8. Gunnar Rätsch

In Oncology

1. Christopher Sander
2. Eric G. Pamer
3. J. Wargo

Citations in the corpus

• Ecological Modeling from Time-Series Inference: Insight into Dynamics and Stability of Intestinal Microbiota (2013, background): “Antibiotic-induced losses of biodiversity increase the risk of bacterial infections [19,20] and the effects can persist for several days after antibiotic treatment [18,19,21].”
• The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. (2014, methodology): “In many instances, a single bacterial taxon can predominate and replace a previously rich and complex distribution of organisms.(3) Some allo-HCST patients, however, maintain intestinal bacterial diversity throughout the course of transplantation.”
• Intestinal Blautia is associated with reduced death from graft-versus-host disease (2015, methodology): “From 2009 through 2012, we sequenced using the Roche 454 platform samples from consecutive patients that met inclusion criteria regarding number and timing of samples for studies previously published [12, 16]; these patients comprised Cohort 1.”
• Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae (2018, background): “…by Proteobacteria, which taxonomically includes K. pneumoniae, leads to a five-fold increase in the risk of bacteremia in allogenic hematopoietic stem cell transplant patients (Taur et al., 2012), suggesting that bacterial density of colonizing strains plays a role in progression to disease.”
• The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. (2018, background): “Analyses of longitudinal fecal samples demonstrated a disruption of the existing state of equilibrium of the gut microbiota postHSCT, with a loss of bacterial diversity and stability, and dominance of Enterococcus, Streptococcus, and various Proteobacteria (Holler et al., 2014; Taur et al., 2012).”