Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

By Jiandie D. Lin, Hai-Ping Wu, Paul T. Tarr, Chen-Yu Zhang, Zhidan Wu, O. Boss, L. F. Michael, P. Puigserver, E. Isotani, E. Olson and 3 more. Nature, 2002

2,396 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/bc1ca47ae507d0cccc8a94fcef16c137f83e4f30

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Citations in the corpus

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “…of skeletal muscle fibers, as the metabolic actions of these transcriptional regulators are stimulated by SIRT1-mediated deacetylation, leading to the promotion of oxidative muscle function (Frescas et al., 2005; Gross et al., 2008; Handschin et al., 2007; Lin et al., 2002; Rodgers et al., 2008).”
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis (2014, background): “Many of the best known benefits of endurance training, such as fiber type switching,mitochondrial biogenesis, and resistance to muscle atrophy, can be stimulated by expression of the transcriptional coactivator PGC1a in the skeletal muscle (Lin et al., 2002).”
Transcriptional control of mitochondrial biogenesis and function. (2009, background): “, effects similar to ones seen in mice overexpressing PGC-1α (103, 122).”
Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging (2009, background): “Therefore, we studied muscle aging in a mouse model with a MCK-PGC-1 transgene, which is expressed in all skeletal muscles and results in PGC-1 protein levels equal to those found endogenously in type 1 muscle (6).”
The physiology and pathophysiology of nitric oxide in the brain. (2005, background): “, 2003), and mice overexpressing PGC-1alfa have a larger number of mitochondria in cardiac and skeletal muscles (Lin et al., 2002).”
Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “Transcription factor targets of the PGC-1 coactivators Transcription factor PGC-1α PGC-1β Function References NRF-1 + + mitochondrial genes Wu et al., 1999 NRF-2 + ND mitochondrial genes Mootha et al., 2003 PPARα + + fatty-acid oxidation Vega et al., 2000 PPARβ/δ + ND fatty-acid oxidation Wang et al”
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones (2004, background): “…addressed the role of transcriptional control in cellular adaptation to mitochondrial dysfunction (Liao and Butow, 1993; Amuthan et al., 2001) and have begun to shed light on mechanisms that coordinately upregulate nuclear genes encoding mitochondrial proteins (Wu et al., 1999; Lin et al., 2002).”