Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons.

By Aaron D. Pilling, Dai Horiuchi, C. Lively, W. Saxton. Molecular Biology of the Cell, 2006

711 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e6fc59aed44977a2a4d75dcdc354b8be6d729aaa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. C. Chan
2. Prashant Mishra
3. Zu-Hang Sheng
4. Qian Cai
5. E. Holzbaur
6. G. Davis
7. P. Hollenbeck
8. W. Saxton

In Molecular Biology

1. Prashant Mishra
2. Zu-Hang Sheng
3. Qian Cai
4. D. C. Chan
5. Alison E. Twelvetrees
6. E. Holzbaur
7. G. Davis
8. P. Hollenbeck

Citations in the corpus

• Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses (2009, neutral): “Mitochondrial trafficking in neurons is mediated by kinesin motors (Hirokawa and Takemura, 2005; Hollenbeck, 1996; Pilling et al., 2006).”
• The Mechanism of Kinesin Regulation by Ca++ for Control of Mitochondrial Motility (2009, neutral): “Retrograde motion of axonal mitochondria is dependent on dynein rather than kinesin (Hollenbeck and Saxton, 2005; Pilling et al., 2006).”
• AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION (2014, background): “, 2006; Wang and Schwarz, 2009), suggesting that the activity of oppositely directed motors is coordinated (Pilling et al., 2006).”
• The axonal transport of mitochondria (2005, background): “appear anchored or are otherwise stationary (Miller and Sheetz, 2004; Morris and Hollenbeck, 1993; Morris and Hollenbeck, 1995; Ohno et al., 2011; Pilling et al., 2006).”
• Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration (2012, background): “Members of the kinesin-1 family (collectively known as KIF5) have a key role in the anterograde transport of neuronal mitochondri”
• Metabolic regulation of mitochondrial dynamics (2016, background): “Kinesin motor proteins, particularly the kinesin-1 family, mediate transport in the positive (or anterograde) direction, whereas dyneins mediate transport in the negative (or retrograde) direction (Pilling et al., 2006).”
• Matrix as an Interstitial Transport System (2014, background): “family, primarily kinesin-1, and the cytoplasmic dynein family.(181,182,185,186) The myosin family (primarily myosin V) regulates mitochondrial transport along actin filaments.”
• Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase (2009, background): “For example, mutations in kinesin heavy chain and disruption of the Dynein/Dynactin protein complex cause large axonal aggregates composed of diverse synaptic proteins and organelles including, but not limited to, Syt, CSP, Dap160/Intersectin (Dap160) mitochondria, and Brp [16,17,19].”