Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

By Aziz Sancar, L. Lindsey-Boltz, K. Unsal-Kaçmaz, S. Linn. Annual Review of Biochemistry, 2004

3,477 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bb48b7cdb289e597d4e54e93c233fdf302332620

How researchers see this paper

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In Cell Biology

1. Guido Kroemer
2. L. Galluzzi
3. Dana Branzei
4. M. Foiani
5. D. Slade
6. M. Radman
7. Rebecca S. Y. Wong

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Oliver Kepp
4. Yi Zhang
5. Dana Branzei
6. Susan C. Wu
7. M. Castedo
8. M. Foiani

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. Oliver Kepp
4. M. Castedo
5. Dana Branzei
6. M. Foiani
7. L. Zitvogel
8. Rebecca S. Y. Wong

Citations in the corpus

• Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. (2011, neutral): “5; Sancar et al., 2004; Bray and West, 2005; Kimura and Sakaguchi, 2006).”
• PCNA, the maestro of the replication fork. (2007, neutral): “Nucleotide Excision Repair Nucleotide excision repair (NER) (Sancar et al., 2004) involves PCNA as well.”
• Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis (2010, methodology): “Flow Cytometry Cell staining and enrichment for cell sorting of HSPCs, CMPs, and GMPs were performed as described (Passegué et al., 2005; Santaguida et al., 2009).”
• The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “Per1 Decreases the Levels of Wee1, Cyclin B1, and Cdc2 The Cdc2-cyclin B1 complex, which governs the G2/M progression, is positively regulated by Cdc25 phosphatases and negatively regulated by Wee1 and Myt1 kinases (Sancar et al., 2004; Stark and Taylor, 2004).”
• Immunogenicity of induced pluripotent stem cells (2011, neutral): “As an apparent difference between mouse and human cells, p53 is required for the G 2 /M checkpoint in human cells after DNA damage but dispensable for G 2 /M checkpoint in mouse cells (Sancar et al., 2004; Song et al., 2007).”
• Regulation of DNA repair throughout the cell cycle (2008, background): “Endogenous processes can also induce DNA damage; for example, hydrolysis leads to spontaneous DNA depurination; reactive oxygen species (ROS) induce base oxidation and DNA breaks; replication defects can cause mismatches; and replication fork collapse can result in strand break”
• Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. (2006, neutral): “Lastly, DSBs represent obligatory intermediates of physiological DNA rearrangement processes taking place during the development and maturation of the adaptive immune system (V[D]J recombination and immunoglobulin [Ig] heavy chain class switch recombination [CSR]) (Sancar et al., 2004).”
• Maintaining genome stability at the replication fork (2010, background): “Exogenous DNA damage, such as by ultraviolet (UV) irradiation and alkylating agents, and endogenous processes, such as hydrolysis, which leads to spontaneous DNA depurination, or reactive oxygen species that induce base oxidation and DNA breaks, can lead to the formation of bulky lesions (for exam”