Regulation and functions of the IL-10 family of cytokines in inflammation and disease.

By Wenjun Ouyang, S. Rutz, N. Crellin, P. Valdez, S. Hymowitz. Annual Review of Immunology, 2011

1,887 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bb03769771f5abe70a23b7b93fb7c3aac74726f1

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Citations in the corpus

Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, positive): “Therefore, we engineered synNotch T cells that drive the simultaneously production of paracrine inhibitory signal such as the cytokine, IL-10, and the T cell inhibitory ligand, PD-L1, which could drive cell-to-contact inhibition (Chen, 2004; Ouyang et al., 2011).”
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis (2011, methodology): “We then tested cytokines that predominantly activate STAT3, rather than STAT1, such as IL-6, IL-21, IL-22, and IL-23 (Hunter, 2005; Kishimoto, 2005; Kastelein et al., 2007; Spolski and Leonard, 2008; Donnelly et al., 2010; Sabat, 2010; Ouyang et al., 2011).”
Regulation of intestinal epithelial permeability by tight junctions (2012, background): “Interleukin-10 (IL-10), a homodimeric cytokine mainly produced by Th2 cells, regulatory T cells, monocytes/ macrophages, and dendritic cells, is regarded as an antiinflammatory cytokine [130, 131].”
Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “Acting on epithelial cells, IL-22 induces the release of antimicrobial peptides that protect the integrity of the mucosal barrier from pathogens (Ouyang et al., 2011; Sonnenberg et al., 2011).”
The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells (2011, background): “Furthermore, IL-22 was mostly produced by RORgt cells, consistent with the important role of RORgt in regulating IL-22 expression (Ouyang et al., 2011).”
Pathophysiology of Myocardial Infarction (2015, positive): “IL-10, a cytokine predominantly expressed by activated T cells and monocyte/macrophage subsets exerts potent anti-inflammatory actions (279).”
CD4+T Cells: Differentiation and Functions (2012, background): “IL10 is a potent inhibitory cytokine, with the ability to suppress proinflammatory response and thus limits tissue damage by the inflammatory process [131, 147, 148].”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “IL-8 signaling occurs via the MAPK and PI3K pathways, by binding to the IL-8 receptors-CXCR1/2.”