Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

By F. Paris, Z. Fuks, A. Kang, P. Capodieci, G. Juan, Desiree Ehleiter, A. Haimovitz-Friedman, C. Cordon-Cardo, R. Kolesnick. Science, 2001

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Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis (2002, background): “Moreover, lethal irradiation may have an impact on vascular-cell viabilit”
Apoptosis-based therapies (2002, background): “cgi?l=2247">basic fibroblast growth factor , thereby ameliorating radiation sicknes”
The role of p53 in determining sensitivity to radiotherapy (2003, background): “Gastrointestinal (GI) syndrome has been traditionally attributed to the direct IR damage of intestinal epithelia, which undergo p53-dependent apoptosis; however, recent work from Kolesnick's grou”
Strategies to improve radiotherapy with targeted drugs (2011, background): “Some experimental studies have also shown that the inhibition of early ionizing radiation-induced apoptosis in endothelial cells (through a p53-independent inhibition of ceramide production, using specific vascular growth factors, such as fibroblast growth factor 2 (FGF2), or through genetic manipul”
A perivascular niche for brain tumor stem cells. (2007, background): “Evidence indicates that endothelial cells can protect stem cells and tumor cells from radiation damage (Garcia-Barros et al., 2003; Paris et al., 2001).”