The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.

By Frank J. Slack, M. Basson, Zhongchi Liu, V. Ambros, H. Robert Horvitz, Gary Ruvkun, Kimball Way. Molecules and Cells, 2000

799 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ba3def6de599169a7c7da4fd37f16974d8c48db8

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In Aging

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Thomas Tuschl
5. E. Miska
6. M. Jones-Rhoades
7. V. Ambros
8. B. Bartel

In Molecular Biology

1. David P. Bartel
2. Phillip D. Zamore
3. V. Narry Kim
4. Thomas Tuschl
5. M. Jones-Rhoades
6. Frank J. Slack
7. Carlo Maria Croce
8. Scott M. Hammond

Citations in the corpus

• MicroRNA targets in Drosophila (2003, methodology): “However, as the method was developed using known target sites as a guide [4,12,20-25], independent validation and refinement of the method will depend on future experiments.”
• MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. (2003, background): “…Brennecke et al. (2003) employed a GFP reporter transgene as a that let-7 activates lin-29 indirectly, by repressing the microRNA sensor, with regions of the GFP mRNA engineered to be translation of lin-41 messenger RNA (Slack et al., 2000). precisely complementary to the bantam microRNA.”
• MicroRNA functions in animal development and human disease (2005, background): “…timing let-7 microRNA lin-41, hbl-1, Stem cell differentaition LOF Reinhart et al., 2000; daf-12, pha-4 Abrahante et al., 2003; Lin et al., 2003; Slack et al., 2000; Grosshans et al., 2005 Developmental timing miR-48, miR-84, hbl-1 Stem cell differentaition LOF Abbott et al., 2005; Lin et al.,…”
• MicroRNAs and other tiny endogenous RNAs in C. elegans. (2003, background): “In some miRNA families (exemplified by the lin-4 and let-7 families), sequence similarity is greatest in the 5 portion of the miRNA sequence (Figure 2), consistent with target recognition primarily via these 5 sequences [6, 22, 42 ].”
• Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis (2005, background): “elegans larval development and triggers passage from late larval to adult cell fates (11,12).”
• MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. (2011, background): “elegans also regulated the expression of target gene lin-41, which regulated the developmental timing in the worm (2, 74, 75).”
• The microRNAs of Caenorhabditis elegans. (2003, background): “A second tiny riboregulator, let-7 RNA, is expressed later in development and appears to act in a similar manner to trigger the transition to late-larval and adult stages (Reinhart et al. 2000; Slack et al. 2000).”
• Principles of MicroRNA–Target Recognition (2005, neutral): “elegans [17,45].”
• Regulation of miRNA expression during neural cell specification (2005, background): “specific miRNA regulate genes that control critical cellular functions such as terminal differentiation (Lee et al., 1993; Euling and Ambros, 1996; Moss et al., 1997; Slack et al., 2000), apoptosis (Brennecke et al.”
• Computational and experimental identification of C. elegans microRNAs. (2003, background): “complementary sites in the 3′ untranslated region (UTR) of their target mRNAs and repressing their translation (Lee et al., 1993; Wightman et al., 1993; Reinhart et al., 2000; Slack et al., 2000).”