Ferroptosis is a type of autophagy-dependent cell death.
By Borong Zhou, Jiao Liu, R. Kang, D. Klionsky, Guido Kroemer, D. Tang. Seminars in Cancer Biology, 2020
963 citations recorded by the source corpus.
Macroautophagy (hereafter referred to as autophagy) involves an intracellular degradation and recycling system that, in a context-dependent manner, can either promote cell survival or accelerate cellular demise. Ferroptosis was originally defined in 2012 as an iron-dependent form of cancer cell death different from apoptosis, necrosis, and autophagy. However, this latter assumption came into question because, in response to ferroptosis activators (e.g., erastin and RSL3), autophagosomes accumulate, and because components of the autophagy machinery (e.g., ATG3, ATG5, ATG4B, ATG7, ATG13, and BECN1) contribute to ferroptotic cell death. In particular, NCOA4-facilitated ferritinophagy, RAB7A-dependent lipophagy, BECN1-mediated system xc- inhibition, STAT3-induced lysosomal membrane permeabilization, and HSP90-associated chaperone-mediated autophagy can promote ferroptosis. In this review, we summarize current knowledge on the signaling pathways involved in ferroptosis, while focusing on the regulation of autophagy-dependent ferroptotic cell death. The molecular comprehension of these phenomena may lead to the development of novel anticancer therapies.
Subfields: Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/b9fda80a38c4901234facf2bd67dd56bf96f884e
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Citations in the corpus
- Ferroptosis, necroptosis, and pyroptosis in anticancer immunity (2020, background): “Recent studies also defined ferroptosis as a type of autophagy-dependent cell death [64].”
- Ferroptosis: mechanisms and links with diseases (2021, background): “Similarly, lipophagy, which is a form of selective autophagy that leads to the autophagic degradation of intracellular lipid droplets (LDs), also can regulate ferroptosis.(165) The knockdown of the LD cargo receptor RAB7A can inhibit ferroptosis.”
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Ferroptosis is also activated by components of the autophagy machinery, such ATG3, ATG5, ATG4B, ATG7, ATG13, and BECN1 [65].”
- Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Therefore, ferroptosis may be a type of autophagy‐dependent cell death.(470) F IGURE 12 Multiple neuronal cell death pathways are involved in ischemic stroke.”
- Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “Autophagy can coincide with apoptosis, the most common form of the RCD, as well as with non-apoptotic forms of RCD including ferroptosis (Zhou et al., 2019).”
- Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “Accumulating evidence indicates that ferroptosis requires the autophagy machinery for its execution [6].”
- Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “47 Autophagy pathway Ferroptosis exhibits a dependence on autophagy in various induction mechanisms, 265 referring to ferritinophagy, lipophagy, mitochondrial autophagy, clockophagy, and chaperone-mediated autophagy (CMA) (Fig.”