The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.
By Chieh Chang, Zena Werb. Trends in Cell Biology, 2001
726 citations recorded by the source corpus.
Subfields: Cancer Research, Immunology and Allergy, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/b9a4954a079c6dcd08a594f15b48ba394b46ab68
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In Cancer Research
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Citations in the corpus
- Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “…factors so that they become available to cells that are not in direct physical contact, degradation of ECM so that founder cells can move across the tissues into nearby stroma, and regulated receptor cleavage in order to terminate migratory signaling and cell migration (Chang and Werb, 2001).”
- Tight junctions and the modulation of barrier function in disease (2008, background): “Cytokine-promoted opening of the BBB has been shown to occur due to degradation and decreased synthesis of TJ proteins (Chang and Werb 2001; Harkness et al. 2000; Silwedel and Förster 2006; Yang et al. 2006), resulting in compromised junctional integrity.”
- Interstitial flow and its effects in soft tissues. (2007, background): “The clinical relevance of such treatments is still unclear, however, as disruption of the tumor ECM not only allows easier interstitial transport of potential therapeutics, but it also lowers the barriers to tumor cell metastasis (123, 124).”
- The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (2003, background): “These enzymes are the principle agents responsible for extracellular matrix degradation and remodeling, and play important roles in development, wound healing, and in the pathology of diseases such as arthritis and cancer (Chang and Werb 2001).”
- A gene regulatory network orchestrates neural crest formation (2008, background): “In contrast to the abnormal, improperly regulated cancer environment, NC cells respond to precise signals and penetrate the basement membrane in a controlled manner; it is currently thought that they obtain this control by finely regulating the balance between MMPs and tissue inhibitors of MMPs (TIM”
- Zinc transporters and the cellular trafficking of zinc. (2006, background): “The proteolytic activity of these secreted proteins are required for developmental processes such as organ branching, morphogenesis, angiogenesis, and extracellular matrix remodeling [80].”