Zinc transporters and the cellular trafficking of zinc.

By D. Eide. Biochimica et Biophysica Acta, 2006

871 citations recorded by the source corpus.

Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or structural cofactor for many different proteins. Zinc-dependent proteins are found in the cytoplasm and within many organelles of the eukaryotic cell including the nucleus, the endoplasmic reticulum, Golgi, secretory vesicles, and mitochondria. Thus, cells require zinc transport mechanisms to allow cells to efficiently accumulate the metal ion and distribute it within the cell. Our current knowledge of these transport systems in eukaryotes is the focus of this review.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/d0bf13e29c79e60038d0abf041c57a87f3232d2f

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Citations in the corpus

Zinc and human health: an update (2011, positive): “On the other hand, there are cases of acute and chronic Zn poisoning, since excess zinc is toxic for the cell (Pagani et al. 2007); therefore, the cellular level of zinc must be controlled within a suitable range, which is normally between 0.1 and 0.5 mM (Eide 2006).”
Enrichment of cereal grains with zinc: Agronomic or genetic biofortification? (2007, background): “Evidence is available showing a potential role of ZIP family Fe and Zn transporter proteins in improving micronutrient density in grain (Schachtman and Barker 1999; Eide 2006).”
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations (2020, background): “In humans, the intracellular level of zinc is tightly regulated by two major Zn2+ transporter families, the SLC39 (ZIPs) family and the SLC30 (ZnTs) family (Eide, 2006).”