Microbiota-mediated colonization resistance against intestinal pathogens

By C. Buffie, Eric G. Pamer. Nature reviews. Immunology, 2013

1,423 citations recorded by the source corpus.

Commensal bacteria inhabit mucosal and epidermal surfaces in mice and humans, and have effects on metabolic and immune pathways in their hosts. Recent studies indicate that the commensal microbiota can be manipulated to prevent and even to cure infections that are caused by pathogenic bacteria, particularly pathogens that are broadly resistant to antibiotics, such as vancomycin-resistant Enterococcus faecium, Gram-negative Enterobacteriaceae and Clostridium difficile. In this Review, we discuss how immune- mediated colonization resistance against antibiotic-resistant intestinal pathogens is influenced by the composition of the commensal microbiota. We also review recent advances characterizing the ability of different commensal bacterial families, genera and species to restore colonization resistance to intestinal pathogens in antibiotic-treated hosts.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b99cd2c19a35cdf451d0ea08a953f42c6f875cbf

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Citations in the corpus

Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review (2023, background): “Furthermore, gut microbiota is involved in the maintaining of the integrity of the intestinal epithelial barrier, in the protection against exogenous pathogens, in the maturation of the host gut immune system, and in the metabolism of xenobiotics [8].”
Role of the Microbiota in Immunity and inflammation (2014, background): “…157, March 27, 2014 ª2014 Elsevier Inc. 127 treatment can allow the domination of intestinal microbiota with drug-resistant microbes such as vancomycin-resistant enterococcus (VRE), a pathogen that causes bloodstream infections in immunocompromised patients (Buffie and Pamer, 2013; Murray, 2000).”
Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “The entry of VREfm into the bloodstream of hospitalized patients is typically preceded by antibiotic exposure, enabling VREfm to become the predominant species in the gastrointestinal tract (45, 46).”
Identification of antimicrobial peptides from the human gut microbiome using deep learning (2022, background): “Developments in sequencing technology have enabled the in-depth understanding of microbiomes, especially in the human gut, the contributions of which to host metabolic and immune health increasingly are being recognized 10–12 .”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “Colonization Resistance The microbiota can confer protection against pathogens, a phenomenon referred to as colonization resistance, which can be severely impaired by antibiotic treatment [4].”
How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “For example, after antibiotic 531 treatment, the composition of the microbiota was demonstrated to be different from the 532 original one, and this modified microbiota may be more prone to colonization by specific 533 bacterial pathogens [98].”
Homeostatic immunity and the microbiota (2017, neutral): “…the microbiota has also been revealed in clinical and experimental settings in which broad antibiotic treatment allow the domination of intestinal microbiota by drug resistant microbes such as Vancomycin Resistant Enterococcus (VRE) or Clostirudium difficile (Buffie and Pamer, 2013; Murray, 2000).”
Antibiotics and the gut microbiota. (2014, neutral): “Indirect factors include the induction of multiple innate immune response pathways and effector molecules (15).”
Role of ROS and Nutritional Antioxidants in Human Diseases (2018, background): “This alters the composition of commensal microbiota in the GI tract and interrupts their ability to establish colonization resistance, thus promoting the invasion of pathogenic bacteria (Buffie and Pamer, 2013; Moura et al., 2015).”
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. (2014, background): “including stimulation of gut immune systemdevelopment, inhibition of potentially pathogenic microbes, and breakdown of otherwise unabsorbable nutrients.(14,15) Prior studies have shown that the intestinal microbiota of patients undergoing allo-HSCT often loses diversity, resulting in domination by a”
Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome (2018, background): “, 2016), and protection against pathogenic organisms (Buffie and Pamer, 2013).”