Cytoplasmic signaling pathways that regulate cardiac hypertrophy.

By J. Molkentin, Gerald W. Dorn II. Annual Review of Physiology, 2001

752 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b93d18c0c50cd46a27698588dd022230dd922e17

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Aik Choon Tan
2. Karen A. Ryall
3. T. Force
4. J. Molkentin
5. J. Heineke
6. R. J. Lefkowitz
7. K. Weeks
8. Bianca C. Bernardo

In Molecular Biology

1. M. Valko
2. J. Heineke
3. Aik Choon Tan
4. Karen A. Ryall
5. J. Molkentin
6. T. Force
7. M. Mazúr
8. J. Telser

Citations in the corpus

• Protein kinase cascades in the regulation of cardiac hypertrophy. (2005, background): “Virtually every cardiomyocyte receptor that couples to Gq stimulates cardiac or cardiomyocyte hypertrophy, the most important of which are the α1-adrenergic receptors for norepinephrine and phenylephrine, the AT-1 receptor for angiotensin II, and the ET receptor for endothelin-1 (38).”
• Systems biology approaches for advancing the discovery of effective drug combinations (2015, background): “Since cardiac myocytes have minimal capacity for proliferation, many of these pathways also regulate proliferation in cancer cells [36].”
• Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. (2010, background): “this, Molkentin et al. (1998) showed that cardiac-specific transgenic mice expressing a constitutively activate mutant form (nuclear”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “…c release may also occur via MPTndependent mechanisms and may involve an oligomeric orm of Bax. hemistry & Cell Biology 39 (2007) 44–84 65 The cells’ growth known as cardiomyocyte hypertrophy, can lead to congestive heart failure and other forms of cardiovascular disease (Molkentin & Dorn, 2001).”
• Regulation of cardiac hypertrophy by intracellular signalling pathways (2006, background): “Ras directly activates RAF1 leading to MEK1–ERK1/2 activation, but it can also activate the JNK branch of the MAPK cascade, PI3K and other intracellular signalling pathway”
• Seven-transmembrane-spanning receptors and heart function (2002, background): “Signals ↑cAMP/PKA ↑cAMP/PKA, MAPK ↑cAMP/PKA ↑DAG/InsP3, ↓cAMP/PKA ↓cAMP/PKA PKC, MAPK ↑PI(3)K”