An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

By Christoph Handschin, James Rhee, Jiandie D. Lin, Paul T. Tarr, B. Spiegelman. Proceedings of the National Academy of Sciences of the United States of America, 2003

684 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b92c1cada975b70596c7cb694dc7dd18f6157787

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Citations in the corpus

Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “…fasted liver (Herzig et al., 2001), calcium signaling through calcium/calmodulin-dependent protein kinase and calcineurin A in exercised skeletal muscle and heart (Handschin et al., 2003; Ojuka et al., 2003; Schaeffer et al., 2004) and adaptive thermogenesis in brown fat (Puigserver et al., 1998).”
Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. (2008, background): “36 Loss of calcineurin in heart results in impaired mitochondrial electron transport associated with high levels of superoxide production.”
Transcriptional control of brown fat determination by PRDM16. (2007, methodology): “Briefly, the -2kbPGC-1α reporter gene (Handschin et al., 2003) or the UCP1 -4kb reporter (a gift from L. Kozak) were transiently transfected with PRDM16 and/or PGC-1α expression plasmids in 12 well plates using Fugene6 (Roche).”
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, positive): “We therefore utilized a PGC1a promoter cloned upstream of the luciferase reporter gene (Handschin et al., 2003) and mutated each E box by site-directed mutagenesis (Figure 3F).”
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle (2005, background): “The mechanism by which this conversion occurs remains incompletely understood, but the current evidence suggests that it involves, at least in part, the induction by cAMP and Ca2+ of PGC-1α, which then activates transcriptional programs of fiber type switching and mitochondrial biogenesis (Czubryt e”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “PGC-1a is well known to often increase the expression of transcription factors that it interacts with, thereby positively regulating its own regulators (Handschin et al., 2003; Mootha et al., 2004).”
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, methodology): “CREB has been found to be an important regulator of PGC-1a expression under normal physiological stimuli (Handschin et al., 2003; Herzig et al., 2001).”