On the allelic spectrum of human disease.

By David Reich, Eric S. Lander. Trends in Genetics, 2001

1,278 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b918f038cb9933bee93276894a2809e220840f80

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Citations in the corpus

Runs of homozygosity in European populations. (2008, result): “These findings are consistent with studies suggesting that the variants associated with increased risk of common complex disease are more likely to be rare than to be common in the population;(35,36) are more likely to be distributed abundantly rather than sparsely across the genome,(37) and are mor”
Genome-wide association studies: theoretical and practical concerns (2005, background): “Allelic spectra of common diseases The allelic spectrum or architecture of a disease refers to the number of disease variants that exist, their allele frequencies and the risks that they confe”
Patterns of linkage disequilibrium in the human genome (2002, background): “It is also worth briefly noting that the use of LD for mapping relies on assumptions regarding the genetic architecture of common diseases that are open to question; this point is discussed extensively elsewher”
Searching for missing heritability: Designing rare variant association studies (2014, background): “However, the speed of approach to this new equilibrium varies substantially depending on s (39).”
Database mining for selection of SNP markers useful in admixture mapping (2009, background): “Moreover, the fundamental theorem underpinning Hap-Map is the common disease common variance (CD/CV) hypothesis [39].”
Rare Variants Create Synthetic Genome-Wide Associations (2010, background): “One possible explanation for this increase due to increasing the number of rare causal variants is that adding more causal variants increases the size of the disease class, which is the proportion of haplotypes that carry one or more disease alleles [8].”
A vision for the future of genomics research (2003, methodology): “More efficient strategies for detecting rare alleles involved in common disease are also needed, as the hypothesis that alleles that increase risk for common diseases are themselves commo”
Genome-wide association studies in diverse populations (2010, background): “A primary use of a population-genetic perspective in the GWA context has been in predicting expected patterns of disease variatio”
Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. (2002, background): “The picture emerging from detailed studies of the limited number of genes that have been identified in complex disorders is one of subtle, rather than striking, relationships between genetic variation, gene function, and increased risk (Risch 2000; Reich and Lander 2001).”