A vision for the future of genomics research

By F. S. Collins, Eric D. Green, A. Guttmacher, Mark Guyer. Nature, 2003

1,818 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/141267eae57f9a64559bedebfc937728fe3e65c4

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Citations in the corpus

Global analysis of protein expression in yeast (2003, background): “jpg" NDATA ITEM> ]> The availability of complete genomic sequences and technologies that allow comprehensive analysis of global expression profiles of messenger RN”
Protein Modelling: What Happened to the “Protein Structure Gap”? (2013, positive): “a possible copying mechanism for the genetic material” (Watson and Crick, 1953) and has initiated a revolution in molecular biology and biomedical research (Collins et al., 2003).”
The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies (2011, background): “To better realize this promise, the National Human Genome Research Institute (NHGRI) called on researchers to determine how genetic variants influence susceptibility towards chronic conditions such as diabetes, Alzheimer’s disease, and cardiovascular disease, in order to ultimately improve patient c”
A User's Guide to the Encyclopedia of DNA Elements (ENCODE) (2011, background): “Interpreting the human genome sequence is one of the leading challenges of century biology [1].”
Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies (2004, background): “The recent assembly of the human reference sequence opens many opportunities for enhancing the accuracy and expanding the application of information on human sequence variants (10).”
Computational prediction of transcription-factor binding site locations (2003, background): “Francis Collins, Director of the National Human Genome Research Institute (USA), has proposed that “the next phase of genomics is to catalog, characterize and comprehend the entire set of functional elements [including those that do not encode protein] encoded in the human and other genomes” [1].”
Distribution and intensity of constraint in mammalian genomic sequence. (2005, background): “This is particularly important in light of the goal of comprehensively identifying functional elements in the finished human sequence (Collins et al. 2003; The ENCODE Project Consortium 2004).”
Chemical space and biology (2004, background): “We have yet, for example, to reap the real benefits of the recent revolutions in genomics and proteomics, which promise to identify a much greater number of well-characterized molecular targets for therapeutic interventio”
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia (2005, background): “Genetic dissection of a complex trait requires disentangling the web of interactions among genes, environment and phenotyp”