Targeting autophagy in cancer
By Angelique Onorati, Matheus Dyczynski, Rani Ojha, R. Amaravadi. Cancer, 2018
1,401 citations recorded by the source corpus.
Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. Early results from clinical trials that repurposed hydroxychloroquine for cancer have suggested that autophagy inhibition may be a promising approach for advanced cancers. In this review of the literature, the authors present fundamental advances in the biology of autophagy, approaches to targeting autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role of autophagy in tumor immunity, and recent developments in next‐generation autophagy inhibitors that have clinical potential. Autophagy is a promising target for drug development in cancer. Cancer 2018. © 2018 American Cancer Society.
Subfields: Epidemiology, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/4b984e0a83d5932a221de9cc62cdabdca5fa7ce2
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In Epidemiology
In Molecular Biology
Citations in the corpus
- Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “265 The MAPK pathway drives the expression of autophagy-related-8 (Atg8) in cancer cells.”