Macrophages in atherosclerosis: a dynamic balance
By K. Moore, Frederick J. Sheedy, E. Fisher. Nature reviews. Immunology, 2013
2,448 citations recorded by the source corpus.
Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall. Through the analysis of the progression and regression of atherosclerosis in animal models, there is a growing understanding that the balance of macrophages in the plaque is dynamic and that both macrophage numbers and the inflammatory phenotype influence plaque fate. In this Review, we summarize recently identified pro- and anti-inflammatory pathways that link lipid and inflammation biology with the retention of macrophages in plaques, as well as factors that have the potential to promote their egress from these sites.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/b850a86b2dd798a288a0321842eb1182eaa83683
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Citations in the corpus
- Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “The continuous monocyte recruitment, foam cell and fatty steak formation eventually result in unstable plaque development, thrombosis, and a cardiac event (345, 346).”
- Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “This destabilizes the entire plaque, facilitating rupture and subsequent formation of an embolus that may result in myocardial infarction, stroke, or other forms of cardiovascular disease (Brophy et al., 2017; Frostegård, 2013; Moore et al., 2013).”
- Macrophage plasticity, polarization, and function in health and disease (2018, background): “…and involve the entry of monocytes into plaques and the retention, emigration, and apoptosis of lesional macrophages (Chinetti-Gbaguidi et al., 2015; Chistiakov, Bobryshev, Nikiforov, 2015; Lu, 2016; Moore et al., 2013; Rolin & Maghazachi, 2014; Tabas & Bornfeldt, 2016; Woollard & Geissmann, 2010).”
- Macrophage activation and polarization: nomenclature and experimental guidelines (2014, positive): “…thioglycollate injection followed by peritoneal lavages is used for generating n systems in mice and humans are sources of tissue-infiltrating macrophages. s according to stimulation of mouse CSF-1 macrophages or human monocyteez and Gordon, 2014; Mosser and Edwards, 2008; Stout and Suttles, 2004).”
- Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “Of these Mhem, Mox, and M4 showmajor immunomodulatory and anti-inflammatory properties (Hu et al. 2015; Naito et al. 2014; Moore et al. 2013).”
- Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “promoting atherosclerosis.(26) The number of macrophages in atherosclerotic lesions increased after Western diet feeding, and daily oral gavage with A muciniphila significantly reduced the amount, as shown by immunofluorescent staining of the macrophage marker monocytes/macrophages antigen (Figure 2”
- The role of macrophages in the resolution of inflammation. (2019, background): “The balance of macrophages in the plaque is dynamic in that both macrophage numbers and the inflammatory phenotype in the plaque influence plaque fate (111, 112).”
- Macrophages: development and tissue specialization. (2015, background): “Specifically, monocytes differentiate in the intima (the innermost layer of the artery) into macrophages that ingest modified lipoproteins via scavenger receptors and secrete inflammatory mediators that can stimulate smooth muscle cell migration and proliferation (80).”