Extreme sensitivity of adult neurogenesis to low doses of X-irradiation.
By S. Mizumatsu, Michelle Monje, Duncan R. Morhardt, Radoslaw Rola, T. Palmer, J. Fike. Cancer Research, 2003
726 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/6c220cf5c9cd3ad1ae87cba73da435b615886afa
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Citations in the corpus
- Radiation-induced brain injury: A review (2012, background): “, 1996), decreased proliferation of the surviving NSC, and decreased NSC differentiation into neurons (Snyder et al., 2001; Monje et al., 2002; Mizumatsu et al., 2003).”
- Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “Inflammation, characterized by an increase in activated microglia, is one factor involved in the suppression of neurogenesis by IRR (Ekdahl et al., 2003; Mizumatsu et al., 2003; Monje et al., 2003; Rola et al., 2004).”
- Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, unknown): “Moreover, the recovery of cell proliferation after 1 week was associated with a decrease in cell death and a consequent increase in the ratio of proliferating to pyknotic cells, suggesting an increase in cell survival at this time (Peissner et al., 1999; Mizumatsu et al., 2003).”
- Adult neurogenesis: from precursors to network and physiology. (2005, background): “X-irradiations (0–15 Gy) decrease the number of BrdU-labeled cells in a dosedependent manner (following a 60 mg/kg injection of BrdU 1 h before death) and the number of cells expressing p34 or Ki-67 in the adult DG (369, 433, 532).”
- Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. (2020, result): “To our knowledge, this trial provides the first definitive clinical evidence that the hippocampal neuroregenerative niche is important to pathophysiology of RT-induced cognitive decline and builds on extensive preclinical work and prior clinical studies.(9,10,12,13,27,28) This trial’s observation of”