Exosomes: proteomic insights and diagnostic potential

By Richard J. Simpson, Justin W. E. Lim, Rob Moritz, Suresh Mathivanan. Espert Review of Proteomics, 2009

1,093 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b777fa7c9611918f395d457babcdeef321e4c9a4

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Citations in the corpus

Exosomal cell-to-cell transmission of alpha synuclein oligomers (2012, background): “Because microRNAs (miRs) have been found in exosomes [37], miR profiling is a powerful tool to definitively characterize exosomes.”
Exosomes and their roles in immune regulation and cancer. (2015, background): “In addition to rotein constituents, exosomes are also comprised of various lipids nd lipid-raft-associated proteins originating either at the plasma embrane or from early/late endosome compartments, includng cholesterol, sphinogmyelin, and flotillins [15,19,20].”
Circulating Exosomal microRNAs as Biomarkers of Colon Cancer (2014, background): “Exosomes are small membrane vesicles of approximately 100 nm that embed protein, lipids, mRNAs, and miRNAs, depending on the origin of the secreting cells [13,14].”
Innovative approaches for cancer treatment: current perspectives and new challenges (2019, methodology): “In recent years, exosomes detection has been validated as a reliable tool for preclinical practice in different cancer types [64], thanks to the identification of their content: double-stranded DNA (dsDNA) [65, 66], messenger RNA (mRNA), micro RNA (miRNA), long non-coding RNA (lncRNA) [67], proteins”
Cancer exosomes trigger fibroblast to myofibroblast differentiation. (2010, positive): “They comprise a ceramide- and cholesterol-rich lipid bilayer membrane (2), an array of membrane and cytosolic proteins (3) and selected RNA species (4).”
ExoCarta as a resource for exosomal research (2012, background): “Originally described three decades ago (6,7), exosomes contain a subproteome of the cells and are found in many bodily fluids (1,8).”
A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. (2015, background): “Exosomes are a discrete population of small (40–150 nm diameter) membranous vesicles that are released into the extracellular space from multivesicular bodies (MVBs) by most cell types [4].”