p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

By A. Villunger, Ewa M Michalak, Leigh Coultas, F. Müllauer, G. Böck, M. Ausserlechner, Jerry M. Adams, A. Strasser. Science, 2003

1,411 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/b729f9e1b738d10e7339b57fecf06586794bd576

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Strasser
2. Douglas R. Green
3. Karen H. Vousden
4. Eyal Gottlieb
5. F. Llambi
6. C. V. Dang
7. Navdeep S. Chandel
8. J. Wells

In Molecular Biology

1. Jerry M. Adams
2. Suzanne Cory
3. A. Strasser
4. Douglas R. Green
5. Simon N. Willis
6. H. Ahsan
7. P. Czabotar
8. M. S. Ola

In Oncology

1. Jerry M. Adams
2. A. Strasser
3. Suzanne Cory
4. Douglas R. Green
5. Simon N. Willis
6. K. Nakano
7. Karen H. Vousden
8. H. Ahsan

Citations in the corpus

• How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? (2017, background): “68,69 Interestingly, additional loss of the BH3-only protein BIM70,71 (i.e., combined loss of PUMA, NOXA plus BIM) provided as potent protection against nutlin-3a and etoposide as loss of p53 (Figure 2).68,69 After treatment with etoposide or nutlin-3a, BIM expression was upregulated inEμMyc lymphom”
• Radiation-induced cell death mechanisms (2010, background): “Additionally, Noxa [44, 46 ] and Bim [43] are other BH3-only proteins which contribute to radiation induced p53-dependent apoptosis.”
• The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (2006, background): “, 2005), in part by p53-induced upregulation of Noxa (Shibue et al., 2003; Villunger et al., 2003).”
• TIGAR, a p53-inducible regulator of glycolysis and apoptosis. (2006, background): “, 1995), and the expression of the BH3-domain protein PUMA is an essential component of p53-activated apoptotic pathways in several cell types (Jeffers et al., 2003; Villunger et al., 2003).”
• The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “Importantly, the promiscuous binders (e.g. Bim and Puma) are much more potent killers than those that cannot engage all the pro-survival proteins, but the combination of Noxa and Bad potently induces cell death (Figure 2b; Chen et al., 2005).”
• Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “In human cells, p53 requires both BAX and PUMA to efficiently induce apoptosis (Chipuk et al., 2003; Jeffers et al., 2003; Villunger et al., 2003; Yu et al., 2003; Zhang et al., 2000).”