Decoding the Patterns of Self and Nonself by the Innate Immune System
By R. Medzhitov, C. Janeway. Science, 2002
2,234 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/b6e67973ee02d51515392cbd66543bdcb1adc178
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In Immunology
- Zhijian J. Chen
- J. Tschopp
- Guido Kroemer
- Fabio Martinon
- Annick Mayor
- Shizuo Akira
- L. Zitvogel
- Lijun Sun
Citations in the corpus
- Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease (2009, background): “Upon activation, TLRs promote innate and adaptive immune responses, including induction of proinflammatory cytokines and matrix metalloproteinase”
- Points of control in inflammation (2002, background): “That a combination of tissue injury plus infection sustains inflammation helps clarify what provokes an immune respons”
- IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells 1 (2004, background): “T he adaptive immune response evolved to enable the host to eradicate pathogens, but mechanisms also developed to prevent host autoreactivity and damage (1).”
- Innate and acquired immunity in atherogenesis (2002, background): “After receptor ligation, cells either endocytose PAMP-expressing particles or are activated (for example, through nuclear factor-κB), which elicits an inflammatory respons”
- The Arabidopsis Receptor Kinase FLS2 Binds flg22 and Determines the Specificity of Flagellin Perception[W] (2005, background): “The Arabidopsis Receptor Kinase FLS2 Binds flg22 and”
- Innate immunity in plants and animals: striking similarities and obvious differences (2004, background): “In addition, a functional innate immune system appears to be essential for the establishment of an efficient adaptive immune response (6, 13).”
- The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “In addition, the complement system clears modified self cells, such as apoptotic cells and cellular debris, to protect against autoimmunity (reviewed in Medzhitov & Janeway 2002, Carroll 2004, Zipfel et al. 2007, Ricklin et al. 2010).”