Adiponectin acts in the brain to decrease body weight

By Yong Qi, N. Takahashi, S. Hileman, H. Patel, A. Berg, U. Pajvani, P. Scherer, R. Ahima. Nature Medicine, 2004

839 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/b669b6593445f2f24f13aef859614fbca1664811

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. Toshimasa Yamauchi
5. J. Oakhill
6. Takashi Kadowaki
7. S. Galic
8. G. Steinberg

In Epidemiology

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. Takashi Kadowaki
5. M. Trujillo
6. Toshimasa Yamauchi
7. J. Oakhill
8. S. Galic

In Physiology

1. H. Fang
2. R. L. Judd
3. P. Scherer
4. M. Trujillo
5. Toshimasa Yamauchi
6. Takashi Kadowaki
7. G. Steinberg
8. J. Oakhill

Citations in the corpus

• Adiponectin Regulation and Function (2018, positive): “…tissue-brain crosstalk in the regulation and maintenance of fat levels and energy expenditure (147) A number of rodent studies have demonstrated that the central actions of adiponectin to inhibit food intake and stimulate energy expenditure can lead to a decrease in body weight (46, 147, 260).”
• Adiponectin: mechanistic insights and clinical implications (2012, background): “How relevant are the actions in the brain? Adiponectin can easily be detected in cerebrospinal fluid [69], and has potent central effects pharmacologically to decrease body weight and increase energy expenditure [70, 71].”
• Adipose tissue-derived factors: impact on health and disease. (2006, background): “results in decreased body weight and fat mass (96).”
• Adiponectin: action, regulation and association to insulin sensitivity (2005, background): “Qi and co-workers (56) have found the adiponectin concentration in the cerebrospinal fluid (CSF) to be 1–4% of the serum concentration indicating a transport of adiponectin from the serum to CSF.”
• Adiponectin and adiponectin receptors. (2005, background): “Furthermore, it is possible that adiponectin stimulates insulin secretion and/or regulates energy homeostasis (99, 100).”
• Adipose tissue as an endocrine organ. (2010, result): “This may be an important point of difference between a revious study which infused HMW recombinant adiponectin into he brain and found it induced weight loss and increased energy xpenditure (Qi et al., 2004).”
• Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle? (2008, background): “weight (67), the confounding effects of protein-energy wasting”
• Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). (2013, background): “In insulin-deprived animals, muscle protein breakdown is significantly increased, a process that is mediated by the proteasome-ubiquitin pathway.(110,111) Enhanced protein catabolism applies to insulin-deficient and insulinresistant states.”