The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

By B. Hawkins, T. Davis. Pharmacological Reviews, 2005

2,608 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b62630b7b0d5491c83bf4b12b7d2a7ee67759aea

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Citations in the corpus

The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “However, EC-Fig speci ﬁ c accessory proteins were identi ﬁ ed in brain endothelium TJs, such as cingulin, AF-6 and 7H6 [41], whereas some epithelial TJ proteins have not been detected so far at the BBB (like the CRUMBS/ PALS-1/PAT-J and PAR-3/PAR-6/aPKC complexes) [42,43].”
Axon-glial signaling and the glial support of axon function. (2008, background): “Astrocytes have been implicated in forming the blood-brain barrier (Hawkins & Davis 2005), neurotransmitter reuptake (Hertz & Zielke 2004), metabolic coupling of synaptic activity (Magistretti 2006), and injury response.”
3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “Furthermore, the BBB regulates active and passive transport of solutes into the brain [9,10], posing an obstacle to drug delivery for the treatment of neurological diseases and brain tumors [11,12].”
From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery (2016, background): “1α,25-dihydroxyvitam D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood–brain barrier.”
A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics (2022, background): “The endothelial cells are further linked to a continuous barrier through inter-endothelial junctions, restricting the transport of water-soluble substances [69,70].”
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “The tight junctions transmembrane proteins claudins, tricellulin, and occludin restrict paracellular diffusion of watersoluble substances from blood to the brain (Hawkins and Davis, 2005).”
The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction (2009, background): “The inter-endothelial tight junctions in CNS microvessels are an intricate complex of transmembrane (claudins, occludin, and junctional adhesion molecule (JAM)-A) and cytoplasmic (zonula occludens (ZO)-1 and ZO-2, cingulin, AF-6, and 7H6) proteins linked to the actin cytoskeleton [13, 14] (Fig.”
Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat (2007, background): “Occludin is a 65-kDa phosphoprotein that assembles with claudin-5 into heteropolymers and intramembranous strands; it is a regulatory protein that can alter paracellular permeability (Tsukita and Furuse, 2000; Hirase et al, 2001; Hawkins and Davis, 2005).”
CNS immune privilege: hiding in plain sight (2006, background): “The presence of endothelial tight junctions in the intact BBB has long been presumed to prevent leukocyte movement from the blood into the CNS (63, 66).”