Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat

By Yi Yang, Eduardo Y. Estrada, Jeffrey F. Thompson, Wenlan Liu, Gary A. Rosenberg. Journal of Cerebral Blood Flow and Metabolism, 2007

1,040 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “Yang et al.(102) show increased MMP-2 and MMP-9 mRNA and activity levels after reperfusion in spontaneously hypertensive rats with middle cerebral artery occlusion (MCAO).”
Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease (2009, background): “Activated MMP9 can degrade basement membranes, extracellular matrix proteins and tight junction proteins subsequently damaging the integrity of the BBB [31, 71, 100] and potentially leading to spontaneous cerebral hemorrhages.”
The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, positive): “Claudin-5 is degraded by MMP-2 and MMP-9 after an ischemic insult, and both claudin-5 and occludin were found in the surrounding astrocytes, but not in the brain endothelium, after the BBB disruption (Yang et al., 2007).”