Regulation and function of the p53 tumor suppressor protein.

By K. Ryan, A. Phillips, Karen H. Vousden. Current Opinion in Cell Biology, 2001

736 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b60abfb552dd229506d772f0fe9428bb3f8e43a2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. (2003, background): “Post-translational modifications to p53 and Mdm2, subcellular redistribution, inhibition of Mdm2 activity and direct repression of Mdm2 transcription are all mechanisms exploited by the cell to promote the rapid accumulation of p53 [3].”
Regulation of HDM2 activity by the ribosomal protein L11. (2003, background): “In pathways that lead to p53 phosphoryation or ARF activation (Ryan et al., 2001).”
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks (2004, background): “…by members of the Bcl-2 family (Gross et al., 1999; Kroemer, 1999) including proapoptotic p53 transcriptional targets like Bax, Bak, Noxa, and PUMA (Bartke et al., 2001; Ryan et al., 2001; Yu et al., 2001) and antiapoptotic members like Bcl-2 and Bcl-xL (for a review, see Sordet et al., 2003).”
Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence (2002, background): “p53 plays a key role in the control of cell growth, apoptosis and DNA repair, and is activated in response to many forms of stress (reviewed in Vogelstein et al., 2000; Ryan et al., 2001).”
Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “…lead to in- Given the importance of Bcl-2 family members in regulating the intrinsic apoptotic pathway, it is not surprisingcreases in reactive oxygen species (ROS) (Hwang et al., 2001; Moroni et al., 2001; Ryan et al., 2001; Stambolic et that these genes are altered in tumor samples (Table 1).”
ATM and related protein kinases: safeguarding genome integrity (2003, background): “The oncogenic protein MDM2 is both a direct and indirect inhibitor of p53, as it serves as a ubiquitin ligase in p53 ubiquitylation, which mediates its proteasome-mediated degradatio”