Regulation of HDM2 activity by the ribosomal protein L11.

By M. Lohrum, R. Ludwig, M. Kubbutat, M. Hanlon, Karen H. Vousden. Cancer Cell, 2003

686 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/302c3887a95201aa2ebe09da9c377c00b68089fc

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Citations in the corpus

Ribosomal proteins: functions beyond the ribosome. (2015, background): “Later on, more mutations in other RP-encoding genes, including RPS7 (Gazda et al., 2008), RPS10 (Doherty et al., 2010), RPS15 (Gazda et al., 2008), RPS17 (Cmejla et al., 2007), RPS24 (Gazda et al., 2006; Campagnoli et al., 2008), RPS26 (Doherty et al., 2010), RPS27A (Gazda et al., 2008), RPS28 (Grip”
How Common are Extra-ribosomal Functions of Ribosomal Proteins? (2009, background): “The identification of MDM2 (and its human ortholog HDM2) as an E3 ligase responsible for the ubiquitination of p53, leading to its rapid degradation (reviewed in Vazquez et al., 2008), suggested a functional role for the interaction of L5 with MDM2.”
Ribosomopathies: human disorders of ribosome dysfunction. (2010, methodology): “[89] MDM2 has also been shown to bind specifically to several free ribosomal proteins including RPL5, RPL23, RPL11, RPS7 and RPL26 [90-96].”
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. (2007, background): “This coordinated commitment to cell division is monitored and regulated by several types of p53-mediated intrinsic and extrinsic stress signals, such as low levels of ribonucleoside triphosphate pools in the cell (18, 19), low levels of ribosome biogenesis (20), hypoxia, DNA damage, or even oncogene”
Awakening guardian angels: drugging the p53 pathway (2009, background): “One of the clearest effects of actinomycin D is to inhibit ribosomal RNA synthesis, which disrupts the nucleoli and prevents ribosome biogenesis, thus causing the release of the ribosomal protein L11 ( RPL11 ) and RPL5 , which bind and inactivate MDM2 (Ref”
The p53 pathway: positive and negative feedback loops (2005, background): “The MDM-2 protein has been shown to bind specifically to three large ribosomal subunit proteins L5, L11 and L23 (Marechal et al., 1994; Lohrum et al., 2003; Zhang et al., 2003; Dai et al., 2004), and the binding of L5 (Dai and Lu, 2004) or L11 (Lohrum et al., 2003; Zhang et al., 2003) to MDM-2 lower”
p53 in health and disease (2007, background): “Similarly, the ribosomal protein L11 has a role in activating p53 in response to ribosomal stress without a requirement for AR”
p53 ubiquitination: Mdm2 and beyond. (2006, background): “Ribosome proteins such as L11 and L23 can all inhibit the activity of Mdm2 on p53 (Dai et al., 2004; Lohrum et al., 2003; Zhang et al., 2003).”
The MDM2-p53 interaction. (2003, background): “This MDM2/L11 interaction might represent a pathway for p53 stabilization in response to perturbations in ribosome biogenesis (107).”