Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization

By Maria, Grant, Stratford May, S. Caballero, Gary, J. A., Brown, Steven, Guthrie, Robert and 10 more. Nature Medicine, 2002

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Wound Healing: A Cellular Perspective. (2019, background): “Early studies indicated that both hematopoietic stem cells (HSCs) and non-hematopoietic progenitor cells, predominantly EPCs, contribute to regenerating blood vessels (64, 154, 305, 325, 400, 412).”
Hypoxia-induced angiogenesis: good and evil. (2011, background): “In models of ischemiainduced neovascularization, including FAL, tumors, wound healing, and choroidal neovascularization, CACs have been shown to incorporate into new blood vessels and promote neovascularization.(116,129,134,137,140-145) SDF-1/CXCR4 and VEGF/VEGF-R2 signaling regulate the recruitment”
The mouse retina as an angiogenesis model. (2010, background): “The resulting reduction in retinal blood flow leads to retinal ischemia, vascular leakage and retinal neovascularization resembling the clinical picture of patients with retinal vein occlusions.(123) Scheppke et al.”
Stem cell plasticity: time for a reappraisal? (2005, positive): “In murine studies, a single GFP-expressing Sca1cKitLin cell injected into lethally irradiated mice resulted, after ischemia-induced laser occlusion, in the incorporation of donor-derived GFP endothelial cells into retinal neovessels.(77) In another study, Lin progenitors were intravitreally injected”