The biology of incretin hormones.

By D. J. Drucker. Cell Metabolism, 2006

2,242 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/b5bd01868971b5108fce51713cc348ef996bb103

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

In Molecular Biology

In Surgery

Citations in the corpus

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, neutral): “As discussed earlier, GLP-1 has a growth-promoting effect on β-cells and enhances proliferation and protects against apoptosis [411].”
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans (2013, background): “GLP-1 also suppresses appetite, resulting in reduced adiposity (1, 2).”
Incretin hormones: Their role in health and disease (2018, background): “GIP is synthesized as a precursor propeptide (pro-GIP), which is then cleaved to GIP by post-translational processing.(11) Glucagon-like peptide-1 was identified as part of the gene sequence coding for proglucagon,(12) which is expressed in L cells in the small and large intestines, with a gradient ”
Incretin-based therapies for type 2 diabetes mellitus (2009, background): “was followed by major advances in our understanding of how GLP-1 regulates glucose metabolism”
Bioactive protein hydrolysates in the functional food ingredient industry: Overcoming current challenges (2017, background): “These hormones act on pancreatic βcells and stimulate insulin secretion.((165)) Both GLP-1 and GIP exert actions well beyond the β cell.”
Mechanisms linking obesity to insulin resistance and type 2 diabetes (2006, background): “These are produced in the intestinal mucosa and are responsible for the enhancement of the insulin response observed after oral — compared with intravenous — glucose administratio”
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus (2009, background): “However, in short-term studies, from several months to 1 year, both sitagliptin and vildagliptin (98,99,299,300) reduce the postprandial plasma glucose concentration while maintaining the plasma insulin response, indicating a positive effect on FIG.”