Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus

By P. McCray, L. Pewe, C. Wohlford-Lenane, M. Hickey, L. Manzel, Lei Shi, Jason Netland, H. Jia, Carmen M. Halabi, C. Sigmund and 4 more. Journal of Virology, 2006

954 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/b5a6ebd8b39550a2540e1cfec89ecdc24fbd23b5

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Citations in the corpus

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis (2020, positive): “Previously, several hACE2 transgenic mice have been generated with different strategies and used for modeling SARSCoV infection (McCray et al., 2007; Tseng et al., 2007).”
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells (2020, positive): “Additionally, in vivo experiments confirmed that BD-368-2 could provide strong therapeutic efficacy and prophylactic protection against SARSCoV-2, using the hACE2 transgenic mice model (Bao et al., 2020; Yang et al., 2007; McCray et al., 2007).”
Coronavirus Pathogenesis (2011, background): “Transgenic mouse models in which human ACE2 was expressed in the respiratory tract as well as other tissues have been developed (McCray et al., 2007; Tseng et al., 2007).”
A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures (2020, background): “Together, these data describe critical new animal models, demonstrate countermeasure potential and provide key recombinant viruses for further mouse adaptation, leading to 2 nd generation mouse models of human disease.”
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues (2020, neutral): “fascicularis models for SARS-CoV-2 (Bao et al., 2020; McCray et al., 2007; Munster et al., 2020; Rockx et al., 2020; Smits et al., 2011).”
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (2019, background): “After an intranasal infection, both HCoV-OC43 and SARS-CoV were shown to infect the respiratory tract in mice and to be neuroinvasive [261] [262] [263] [264] [265] .”
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (2008, methodology): “In all studies that examined brain sections from SARS patients, virus was detected almost exclusively in neurons (14, 20, 53), consistent with studies showing a marked neuronal tropism in infected hACE2 Tg mice (32, 49).”
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis (2020, positive): “One of these strategies is to genetically modify mice to express human ACE2 (hACE2) (humanized mice) under the epithelial cell-specific cytokeratin-18 (Krt(18)) promoter [114], a universal chicken beta-actin promoter [115], or the endogenousmACE2 promoter [113].”