Fibronectin fibrillogenesis, a cell-mediated matrix assembly process.

By Yong Mao, J. Schwarzbauer. Matrix Biology, 2005

792 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/b5a1afd4aa93b94f303abdd19ea27897ab54d01a

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In Cancer Research

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Citations in the corpus

Targeting the tumour vasculature: insights from physiological angiogenesis (2010, background): “This tight interaction mediates blood vessel stabilization, but can be antagonized by ANGPT2 expressio”
Extracellular matrix dynamics in development and regenerative medicine (2008, background): “The extracellular matrix (ECM), once thought to function only as a scaffold to maintain tissue and organ structure, regulates many aspects of cell behavior, including cell proliferation and growth, survival, change in cell shape, migration, and differentiation.”
Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease (2010, background): “Furthermore, fibronectin promotes cell adhesion, cell migration, and cytoskeletal organization (32).”
Cell–matrix adhesion (2007, background): “…there are already many applications of matrix molecules and synthetic biomaterials to tissue engineering that speed wound repair and potentially replace failed organs (Lutolf and Hubbell, 2005; Maskarinec and Tirrell, 2005; Clark et al., 2007; Kong and Mooney, 2007; Metcalfe and Ferguson, 2007).”
Assembly of Fibronectin Extracellular Matrix (2010, methodology): “Matrix assembly is enhanced with cells on a 3D fibrillar FN matrix (Mao & Schwarzbauer 2005b).”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “Upon binding, clusters containing multiple bound integrins are pulled apart such that matrix proteins are unwound to reveal self-association domains, permitting homotypic binding, e.g. fibronectin–fibronectin (Mao and Schwarzbauer, 2005).”
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators (2008, background): “Address Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom Corresponding author: Kadler, Karl E (karl.kadler@manchester.ac.uk) Current Opinion in Cell Biology 2008, 20:495–501 Thi”
Adhesion signaling – crosstalk between integrins, Src and Rho (2009, background): “Fibronectin is synthesized as a soluble dimer that can be assembled into an insoluble fibrillar matrix on binding to cell-surface receptors of the integrin and syndecan families (Mao and Schwarzbauer, 2005).”
Balancing forces: architectural control of mechanotransduction (2011, positive): “Fibrillar assembly of the fibronectin matrix is also functionally linked to the forced unfolding of matrix protein domains by integrin receptor”
The extracellular matrix at a glance (2010, background): “Moreover, cell contraction through the actomyosin cytoskeleton and the resulting integrin clustering promotes FN–fibril assembly by exposing cryptic binding sites, thus allowing them to bind one another (Leiss et al., 2008; Mao and Schwarzbauer, 2005; Vakonakis and Campbell, 2007).”