Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease
By Praveen Ballabh. Pediatric Research, 2010
772 citations recorded by the source corpus.
The aim of the study was to determine the incidence of electrographic seizure activity in a prospective cohort of preterm infants and relate it to the presence of cerebral injury. Infants born <30-wk gestation received a median 74 h of continuous 2-channel EEG with amplitude-integrated EEG monitoring in the first week of life. Infants were classified in the abnormal outcome group if they died in the neonatal period and/or had grades 3–4 intraventricular hemorrhage and/or moderate or severe abnormalities on cerebral MRI. Seizures were defined as rhythmic spike and/or wave activity lasting at least 10 s on the raw EEG trace. Eleven of 51 infants monitored had electrographic seizures. These infants were more premature had lower birth weights and a greater proportion had abnormal outcomes. In four infants, seizures preceded ultrasound findings of grades 3–4 intraventricular hemorrhage. Three of the four infants with seizures and concurrent physiologic recordings displayed concurrent rises in heart rate and one showed a fall in respiratory rate. In conclusion, electrographic seizures were more likely to occur in the sicker and more premature infants with abnormal outcomes. Seizures detected on continuous amplitude-integrated EEG monitoring with the raw EEG were associated with poor outcome.
Subfields: Cognitive Neuroscience, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/8ca006d9b4823f37a03e855d3de7e6a64726b6b0
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In Cognitive Neuroscience
In Pediatrics, Perinatology and Child Health
Citations in the corpus
- Central nervous system pericytes in health and disease (2011, positive): “In the human CNS, region-specific reductions in pericyte coverage have been found in hemorrhage-prone, progenitor-rich regions of the developing telencephalon, such as the germinal matri”
- Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species (2013, background): “The SVZ and SGZ may show inherent vulnerability to injury associated with their neurogenic potential and/or their highly vascularized nature during early brain development (Baburamani et al., 2012; Ballabh, 2010).”