Revealing the world of RNA interference

By C. Mello, D. Conte. Nature, 2004

1,037 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b576490e0364c9e0243b2636cec4d578820d7b8d

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In Molecular Biology

Citations in the corpus

Specialization and evolution of endogenous small RNA pathways (2007, background): “In retrospect, it is obvious that many of these differences resulted from the entry of trigger loci or transcripts into distinct silencing pathways that evolved through proliferation and specialization of a basic set of module”
A construct with fluorescent indicators for conditional expression of miRNA (2008, neutral): “Background RNAi is a conserved cellular mechanism that can mediate sequence-specific RNA degradation in eukaryotes [1] and has recently been harnessed for reverse genetics in mammalian cells and transgenic animals [2-5].”
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. (2005, background): “Additionally, some transgene transcripts may be targeted for a different mode of regulation altogether (Grishok et al., 2005; Mello and Conte, 2004).”
RNA-binding proteins in human genetic disease. (2008, neutral): “estimated that � 50% of human genes are alternatively spliced [ 94 ].”
RNAstructure: software for RNA secondary structure prediction and analysis (2010, background): “These new ncRNA sequences range in size from microRNAs to Xist [2,3].”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “As in plants and other systems that contain an RdRP-dependent siRNA amplification mechanis”
Comparing the human and chimpanzee genomes: Searching for needles in a haystack (2005, background): “The wealth of new information being generated about noncoding RNA sequences also makes them an intriguing candidates for potential differences (Eddy 2001; Dykxhoorn et al. 2003; Mello and Conte 2004; Kim 2005; Tang 2005).”
Molecular Approaches Toward Resistance to Plant-Parasitic Nematodes (2008, background): “RNAi occurs by an endogenous cellular pathway, which includes the dicer protein that processes long dsRNAs into 21mers (siRNAs) and the RISC protein complex that guides siRNA-mRNA base pairing and degradation (Mello and Conte 2004) .”