Genome-scale functional characterization of Drosophila developmental enhancers in vivo

By Evgeny Z. Kvon, T. Kazmar, Gerald Stampfel, J. Yáñez-Cuna, Michaela Pagani, K. Schernhuber, Barry J. Dickson, Alexander Stark. 2014

426 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

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Citations in the corpus

Iterative random forests to discover predictive and stable high-order interactions (2017, background): “1 Drosophila Enhancers In total, 7809 genomic sequences have been evaluated for their enhancer activity (Berman et al., 2002; Fisher et al., 2012; Frise et al., 2010; Kvon et al., 2014) in a gold-standard, stable-integration transgenic assay.”
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster (2017, background): “…(e.g. Hige et al., 2015; Wilson et al., 2004), relatively small size (Figure 1A), and the stereotypy of and genetic access to most of the ~100,000 neurons in its brain (Aso et al., 2014; Chiang et al., 2011; Jenett et al., 2012; Kvon et al., 2014; Milyaev et al., 2012; Pfeiffer et al., 2010).”
Enhancer control of transcriptional bursting (2016, neutral): “5 kb is similar to the median separation ( 10 kb) between promoters and developmental enhancers based on whole-genome assays inDrosophila embryos (Kvon et al., 2014).”
FlyBase: a guided tour of highlighted features (2022, background): “2011), GAL4 driver collections(Pfeiffer et al. 2008; Kvon et al. 2014), and sgRNA transgenic fly collections (Jia et al.”
Ever-changing landscapes: transcriptional enhancers in development and evolution (2016, background): “For example, comparison of individual enhancer activity with endogenous gene-expression patterns estimate that the activity of up to 37% of enhancers may be modulated by their extended endogenous loci in Drosophila (Kvon et al., 2014).”
Dissecting neural pathways for forgetting in Drosophila olfactory aversive memory (2015, background): “We collected 47 Gal4 driver lines (37, 49, 50) that had expression in putative MBENs (SI Appendix, Fig.”
The VT GAL4, LexA, and split-GAL4 driver line collections for targeted expression in the Drosophila nervous system (2017, methodology): “The expression pattern of 7,705 VT GAL4 driver lines in the embryo has been determined using in situ hybridization to detect the GAL4 mRNA (Kvon et al., 2014).”
FlyBase at 25: looking to the future (2016, methodology): “We also offer a GBrowse track that depicts the regulatory regions used to generate the Vienna Tiles GAL4 lines available at the VDRC stock center (22,30).”
Generating Customized Transgene Landing Sites and Multi-Transgene Arrays in Drosophila Using phiC31 Integrase (2015, background): “Specifically, in light of the large number of transgenes that have been characterized fol- lowing integration into attP2 (e.g., Jenet et al. 2012; Kvon et al. 2014), we deemed that it would be useful to identify new sites that recapitulate the expression properties of this landing site.”