The VT GAL4, LexA, and split-GAL4 driver line collections for targeted expression in the Drosophila nervous system

By Laszlo Tirian, Barry J. Dickson. bioRxiv, 2017

193 citations recorded by the source corpus.

In studying the cellular interactions within complex tissues, it is extremely valuable to be able to reproducibly and flexibly target transgene expression to restricted subsets of cells. This approach is particularly valuable in studying the nervous system, with its bewildering diversity of neuronal cell types. We report here the generation of over 18,000 driver lines (the VT collection) that exploit the GAL4, LexA, and split-GAL4 systems to express transgenes in distinct and highly specific cell types in Drosophila. We document the expression patterns of over 14,000 of these lines in the adult male brain.

Subfields: Cellular and Molecular Neuroscience, Immunology, Plant Science

View Paper: https://www.semanticscholar.org/paper/21022795136018d19f43fb54b544c4f4ed0a664d

Citations in the corpus

• Metrics Reloaded: Recommendations for image analysis validation (2022, unknown): “• Instance segmentation of neurons from the fruit fly in 3D multi-color light microscopy images [61, 65, 86] (the corresponding traversals through the decision trees are provided in Fig.”