'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake…

By R. Gref, M. Lück, P. Quellec, M. Marchand, É. Dellacherie, S. Harnisch, T. Blunk, R. Müller. Colloids and Surfaces B: Biointerfaces, 2000

1,590 citations recorded by the source corpus.

Subfields: Biomaterials, Pharmaceutical Science, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/b53f7c8a4c0b191c199793be8ffacb2ad982cb2a

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In Biomaterials

1. O. Farokhzad
2. N. Bertrand
3. Miqin Zhang
4. Xiaoyang Xu
5. Alexandre Albanese
6. A. D'Souza
7. S. Minko
8. M. Üner

In Pharmaceutical Science

1. A. D'Souza
2. M. Üner
3. N. Bertrand
4. Dinesh. K. Singh
5. G. Yener
6. R. Shegokar
7. A. Mahapatro

In Surfaces, Coatings and Films

1. S. Minko
2. W. Chan
3. Miqin Zhang

Citations in the corpus

• Cancer Nanomedicine: From Targeted Delivery to Combination Therapy (2015, background): “PEG surface functionalization has been shown to dramatically reduce protein adsorption, particularly apolipoprotein J and complement protein C3, through hydrophilicity and steric repulsion effects, with the effect of extending circulation time in blood [22–24].”
• Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives (2007, background): “This effect is common for PEG-coated nanoparticles due to an extension of the plane of shear of the nanoparticles (Gref et al 2000).”
• Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, background): “Many studies demonstrated that PEGylated liposomes were able to improve the stability and blood-circulation time, together with low plasma clearance and low volume of distribution (with minimal interaction with nontumoral tissues) [57, 83, 84].”
• Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines (2011, positive): “Macro-phages are powerful phagocytic cells and are the important constituent of mononuclear phagocytic system (MPS).”
• Responsive Polymer Brushes (2006, background): “The brush masks the particles from macrophages and results in an increase in the blood circulation half-life of the particles by several orders of magnitude.(110) – 112 The next step could be seen as a fabrication of the particle shell from a mixed spherical brush constituted of polymer chains (whic”
• Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, background): “PEG exhibits selectivity in the deposition of carriers within body.[70] PEG-coated carriers influence its transport through mucosal regions of gastrointestinal tract, [71] pulmonary region, [72] cervico vaginal tract, [73] and tumor site.”
• Magnetic nanoparticles in MR imaging and drug delivery. (2008, methodology): “nanoparticle coating in biomedical applications [28,71].”