Cancer Nanomedicine: From Targeted Delivery to Combination Therapy

By Xiaoyang Xu, William Ho, Xueqing Zhang, N. Bertrand, O. Farokhzad. Trends in Molecular Medicine, 2015

644 citations recorded by the source corpus.

The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of a variety of diseases, including cancer. The unique properties of nanoparticles, such as large surface-to volume ratio, small size, the ability to encapsulate a variety of drugs, and tunable surface chemistry, gives them many advantages over their bulk counterparts. This includes multivalent surface modification with targeting ligands, efficient navigation of the complex in vivo environment, increased intracellular trafficking, and sustained release of drug payload. These advantages make nanoparticles a mode of treatment potentially superior to conventional cancer therapies. This article highlights the most recent developments in cancer treatment using nanoparticles as drug-delivery vehicles, including promising opportunities in targeted and combination therapy.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/72c078260be66e2539e7f2d46275215b3ef2bf14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. Handan Acar
2. Stefan Wilhelm
3. Nathan D. Donahue

Citations in the corpus

• Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “healthy and diseased cells through the use of precise biomolecular recognition strategies [26,27].”