Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

By A. Mahapatro, Dinesh. K. Singh. Journal of Nanobiotechnology, 2011

641 citations recorded by the source corpus.

Biodegradable nanoparticles (NPs) are gaining increased attention for their ability to serve as a viable carrier for site specific delivery of vaccines, genes, drugs and other biomolecules in the body. They offer enhanced biocompatibility, superior drug/vaccine encapsulation, and convenient release profiles for a number of drugs, vaccines and biomolecules to be used in a variety of applications in the field of medicine. In this manuscript, the methods of preparation of biodegradable NPs, different factors affecting optimal drug encapsulation, factors affecting drug release rates, various surface modifications of nanoparticles to enhance in-vivo circulation, distribution and multimodal functionalities along with the specific applications such as tumor targeting, oral delivery, and delivery of these particles to the central nervous system have been reviewed.

Subfields: Biomaterials, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/6f6f8bf08b5dcf1a36a2996bf052f8a917e93c2c

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Citations in the corpus

Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “) to be encapsulated in the polymer, 3) surface characteristics and functionality, 4) degree of biodegradability and biocompatibility, and 5) drug release profile of the final product [114].”
Crossing the blood‐brain barrier with nanoparticles (2018, methodology): “PLGA/PLA NPs as nanocarriers can be hydrolyzed in the body generating lactic acid and glycolic acid, two biodegradable metabolite monomers metabolized through the Kreb's cycle [79].”
Microneedles: A New Frontier in Nanomedicine Delivery (2016, positive): “directly incorporated within the polymeric matrix (133).”
Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “Immunotherapeutic agents have yielded promising results by not only treating primary cancer but by preventing distant metastasis and lowering the rate of recurrence [10].”