NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS.

By M. Dawson, A. Polito, J. Levine, R. Reynolds. Molecular and cellular neurosciences, 2003

912 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b5288388a5aaadc9c6aa6d66fa1701fbebaa2d0e

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In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Cellular and Molecular Characterization of Multipolar Map5-Expressing Cells: A Subset of Newly Generated, Stage-Specific Parenchymal Cells in the Mammalian Central Nervous System (2013, background): “In the adult mammalian CNS, beside de novo cell genesis of ‘classic’ neurogenic sites (SVZ and dentate gyrus [62,63]), the occurrence of local, parenchymal progenitors which continue to divide throughout life has progressively became a new area of investigation [1,2,64,65].”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity (2009, background): “1b–d ), although the number and length of the processes change with the age and location of the cell”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “All of them act, in defined experimental conditions, as multipotent progenitor cells but differ in their origin: reactive astrocytes are of the astroglial origin, pericytes are either mesodermal or neural crest-derived, and NG2 glia are derived from the neuroectoderm (18, 25, 30, 51, 58, 59, 94, 158”
Remyelination in the CNS: from biology to therapy (2008, background): “The consensus (reached largely on the basis of data from rodent studies) is now that in most cases remyelination is mediated by new oligodendrocytes derived from a population of adult CNS stem/precursor cells, most often referred to as adult oligodendrocyte precursor cells (or progenitor cells) (O”
NG2 cells generate both oligodendrocytes and gray matter astrocytes (2007, background): “These cells are distinct from mature oligodendrocytes, astrocytes or resting ramified microglia and represent a fourth major glial population (Dawson et al., 2000; Dawson et al., 2003; Nishiyama et al., 2002; Peters, 2004).”
Physiology of Astroglia. (2018, neutral): “Other numerical estimations set microglia at ~10 15% of all glia in the human brain (1130), whereas NG-2 glia account for another 5 10% (386), so both oligodendrocytes and astrocytes account for ~75% of all neuroglia.”