Glutamine and cancer: cell biology, physiology, and clinical opportunities.

By C. Hensley, Ajla T. Wasti, Ralph J. Deberardinis. Journal of Clinical Investigation, 2013

1,159 citations recorded by the source corpus.

Subfields: Biochemistry, Biotechnology, Cancer Research

View Paper: https://www.semanticscholar.org/paper/b4f7fdb0b7e14eec0e23a17f80120b97c80fdb16

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Navdeep S. Chandel
2. S. Weinberg
3. Laura A. Sena
4. M. V. Vander Heiden
5. C. V. Dang
6. M. Santoro
7. E. Panieri
8. J. Mancias

In Biotechnology

1. Navdeep S. Chandel
2. S. Weinberg
3. Laura A. Sena
4. C. V. Dang
5. Jared Rutter
6. Alec C. Kimmelman
7. Y. Fouad
8. C. Aanei

In Cancer Research

1. Navdeep S. Chandel
2. Ralph J. Deberardinis
3. M. V. Vander Heiden
4. C. V. Dang
5. Alec C. Kimmelman
6. S. Weinberg
7. D. Y. Gui
8. E. Panieri

Citations in the corpus

• Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport (2014, background): “Glutamine serves as an interorgan shuttle of carbon and nitrogen and is the major source of nitrogen for nonessential amino acids, nucleotides, and hexosamines (Hensley et al., 2013).”
• KRAS: feeding pancreatic cancer proliferation (2014, positive): “Glutamine contributes to macromolecular synthesis in cancer cells by providing carbon to fuel the TCA cycle and nitrogen for nucleotide, nonessential amino acid (NEAA), and hexosamine biosynthesis [43,44].”
• Mitochondria in the regulation of innate and adaptive immunity (2015, positive): “Glutamine replenishes the TCA cycle through glutaminolysis, which results in the generation of a-ketoglutarate (Hensley et al., 2013).”
• Glutaminolysis and Transferrin Regulate Ferroptosis (2015, background): “Downstream of glutaminolysis, glutamate can be further converted into α-ketoglutarate (αKG) either by glutamate dehydrogenase (GLUD1)-mediated glutamate deamination or by transaminases-mediated transamination (Hensley et al., 2013) (Figure 5A).”
• Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells (2015, background): “Aspartate Synthesis Is Inhibited by Electron Acceptor Insufficiency For most cells in culture, carbon for de novo aspartate synthesis is supplied by anaplerotic glutamine (DeBerardinis et al., 2007; Hensley et al., 2013).”
• MYC, Metabolism, and Cancer. (2015, background): “a tightly regulated glucose level and more dynamic levels of circulating lipoprotein particles and glutamine, the most abundant plasma amino acid (83).”
• Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation (2018, background): “Cancer cells take advantage of aerobic glycolysis (also known as the Warburg effect), and therefore glucose to maintain the supraphysiological survival and growth [185,186].”
• Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer (2016, background): “Glutamine is an important nutrient for most cancer cells in culture (Hensley et al., 2013; Mayers and Vander Heiden, 2015) and can provide carbon for TCA-cycle anaplerosis in Ras-driven cancer cells (White, 2013).”