Intestinal stem cells protect their genome by selective segregation of template DNA strands.
By C. Potten, G. Owen, D. Booth. Journal of Cell Science, 2002
677 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/b4d395b304313982e178d63bc7162c1dd3016ff6
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Citations in the corpus
- The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, background): “Given the spatial localization of Bmi1 ISCs at the +4 position, where a DNA label-retaining cell has also been described (12, 13), we postulated that Bmi1 marks a quiescent ISC.”
- The intestinal stem cell. (2008, background): “Label retention by the +4 cell has been proposed to result from asymmetric segregation of old and new DNA strands (Potten 1977; Potten et al. 2002).”
- Epithelial stem cells: turning over new leaves. (2007, unknown): “…sites of putative stem cells include the limbal region of the cornea (Cotsarelis et al., 1989), the bulge of the hair follicle (Cotsarelis et al., 1990), the terminal end bud of the mammary gland (Zeps et al., 1998), and a narrow band near the bottom of the intestinal crypts (Potten et al., 2002).”
- Stem cell niche: structure and function. (2005, methodology): “These were based on the adult stem cell’s ability to retain the BrdU or 3H-thymidine labels (Cotsarelis et al. 1990, Potten et al. 2002).”
- Telomeres and aging. (2008, background): “Estimates range from more than 1,000 times for intestinal epithelial cells in rodents (170) to less than 100 times for hematopoietic stem cells in humans (115).”
- Mechanisms and insights into drug resistance in cancer (2013, background): “Beside modulation of molecular mechanisms, such as increased efficiency of DNA repair (Potten et al., 2002; Cai et al., 2004; Park and Gerson, 2005), changes in cell cycle parameters (Venezia et al., 2004), overexpression of anti-apoptotic proteins (Wang et al., 2003) or drug transporters…”