The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication

By P. Bercik, A. Park, D. Sinclair, A. Khoshdel, J. Lu, X. Huang, Y. Deng, P. Blennerhassett, Margaret Fahnestock, D. Moine and 7 more. Neurogastroenterology and Motility, 2011

955 citations recorded by the source corpus.

Subfields: Gastroenterology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/b4cf2faeb533f790483ce2d52d17150808e42b2b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. R. Stilling
4. Emeran A. Mayer
5. S. Mazmanian
6. Yan Wang
7. L. Kasper
8. Ygor P. Silva

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. Yan Wang
4. L. Kasper
5. S. Mazmanian
6. T. Sampson
7. Emeran A. Mayer
8. R. Stilling

In Neurology

1. Emeran A. Mayer
2. Bruno Bonaz
3. Daniel H. Geschwind

Citations in the corpus

• Gut Microbes and the Brain: Paradigm Shift in Neuroscience (2014, background): “Similar changes in BDNF expression have also been reported following antibiotic administration (Bercik et al., 2011b).”
• The Central Nervous System and the Gut Microbiome (2016, background): “A reciprocal effect by gut bacteria has been reported as well, where specific bacteria, or complete microbial assemblages, had effects on host stress- and depression-like behaviors (Bercik et al., 2011a; Gacias et al., 2016; Sudo et al., 2004).”
• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “longum Reduces anxiety-like behavior in a mouse model of chemically induced colitis (Bercik et al., 2011)”
• The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems (2015, background): “In a model of chronic colitis associated to anxietylike behavior, the anxiolytic effect obtained with a treatment with Bifidobacterium longum, was absent in mice that were vagotomized before the induction of colitis [42].”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “…of a different mouse strains is mainly responsible for variations in their gut microbiota (Kovacs et al. 2011) and adoptive transfer of phenotypic strain differences by microbiota transplantations or inter-strain cross-fostering (Bercik et al. 2011a; Collins et al. 2013; Francis et al. 2003).”
• The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis (2018, background): “In addition, Bercik et al. (2011) have shown that Bifidobacterium longum has anxiolytic effects during noninfectious, chronic, low-grade gut inflammation induced by dextran sodium sulfate administration.”
• The role of microbiome in central nervous system disorders (2013, positive): “For example, B. longum NCC3001 can normalize murine hippocampal BDNF expression and L. rhamnosus (JB-1) can exert differential regulation of GABA transcription in different CNS regions (Bercik et al., 2011b; Bravo et al., 2011).”
• The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “Many studies have suggested early-life exposure to Bifidobacterium or Lactobacillus species modulate behavior in mice (244, 245), and whether these more classical probiotic strains could impact the development of ASD in children remains to be seen.”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, result): “This notion is in full accordance with early studies showing that oral inoculation with pathogens or probiotics induces activation of the vagal sensory neurons that innervate the GI affecting the regulation of CNS functions, and this effect is absent in vagotomized mice (32, 58, 60).”