Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future.

By R. Müller, C. Jacobs, O. Kayser. Advanced Drug Delivery Reviews, 2001

1,441 citations recorded by the source corpus.

Subfields: Biomaterials, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/b4bde6e808047ed1d600c4aeb3752f7d09be04ef

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Citations in the corpus

Strategies to Address Low Drug Solubility in Discovery and Development (2013, methodology): “Early descriptions of pearl milling suggested that long milling times (several days) may be required to produce nanosized particles (Merisko-Liversidge et al., 1996; Muller et al., 2001; Hu et al., 2004a).”
Drug Nanoparticles: Formulating Poorly Water-Soluble Compounds (2008, background): “There are various ways in which nanoparticles of poorly water-soluble molecules are generated (Horn and Rieger, 2001; Muller et al., 2001; Rabinow, 2004; Merisko-Liversidge, Liversidge, et al., 2004).”
Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions (2009, background): “For a physically stable nanosuspension solely stabilized by electrostatic repulsion, a zeta potential of ±30 mV is required as a minimum (Müller et al., 2001).”
Nanofibrillated cellulose: surface modification and potential applications (2013, background): “This phenomenon of formation and implosion of the gas bubbles results in cavitation and shockwaves that bring the disruption of the cellulose wall [38, 39].”
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. (2007, background): “Often for drugs with very low aqueous solubility, the achieved increase in dissolution rate is insufficient to provide adequate enhancement of bioavailability [7].”
Insoluble drug delivery strategies: review of recent advances and business prospects (2015, neutral): “These results re ﬂ ect the potency of the nanonization technique in terms of reducing drug load from 22.5 mg/kg (Well-vone s ) to 7.5 mg/ kg, and increasing the activity 2.5-fold 70 .”
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “A linear relationship can be observed [55].”
Nanotechnology: Intelligent Design to Treat Complex Disease (2006, background): “poorly soluble in both aqueous and organic media, which results in poor bioavailability with low and/or erratic absorption when using traditional formulations (10).”