Insoluble drug delivery strategies: review of recent advances and business prospects
By Sandeep Kalepu, V. Nekkanti. Acta Pharmaceutica Sinica B, 2015
1,239 citations recorded by the source corpus.
The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects.
Subfields: Biomaterials, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/49944d4be2a5053161ca2f8d7c02f7aa0aab9235
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Citations in the corpus
- Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design (2023, background): “Patient recruitment, enrollment, monitoring, retention, and medical adherence in the healthcare sector are vital areas that need special attention due to clinical trials.”
- Smart nanoparticles for cancer therapy (2023, background): “282 Adjusting local microenvironment to improve drug solubility is an important strategy to improve drug bioavailability, especially by changing the structure of small molecules to regulate their physical and chemical properties, so as to improve the dissolution, diffusion or absorption properties.”