Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

By Joseph C. Sun, M. Bevan. Science, 2003

1,449 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b39c815102a45f5ce7326c80f75dfe26b7f7789f

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In Immunology

Citations in the corpus

Immunogenic and tolerogenic cell death (2009, background): “Without this additional signal, the activated 'helpless' CTLs function as primary effector T cells but with a short lifespa”
Dendritic cells as therapeutic vaccines against cancer (2005, background): “In particular, CD4 + T cells seem to be crucial for priming long-lived CD8 + T-cell memor”
Helping the CD8+ T-cell response (2004, result): “The other set of results, coming from work in infectious diseases, indicates that, although the primary CTL response to most pathogens is easily measured and seems to be independent of CD4 + T-cell help, there is in fact a requirement for CD4 + T cells to allow the generation of long-lived, functi”
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “Although CD4 + T cells are not required for primary CD8 + T cell responses against pathogens, memory CD8 + T cell numbers and secondary responses to bacterial or viral challenge are decreased over time in a CD4 + T cell–deficient anima”
Toll-like receptor control of the adaptive immune responses (2004, background): “Primary activation of CD8 + T cells requires similar signals from the DCs, whereas memory CD8 + T cell responses require CD4 + T cell hel”
Adoptive-cell-transfer therapy for the treatment of patients with cancer (2003, background): “The recent reports describing a requirement of CD4 + T cells for persistence of CD8 + T cells after an immune respons”