Lipid mediator class switching during acute inflammation: signals in resolution

By B. Levy, C. Clish, Birgitta A. Schmidt, K. Gronert, C. Serhan. Nature Immunology, 2001

1,487 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b38ee0314cfc6d4bd152eacbb303c9692f477608

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. P. Calder
2. C. Serhan
3. B. Levy
4. M. Perretti
5. Paul Martin
6. Oscar A. Peña
7. Chuanshu Huang
8. Haitian Lu

In Molecular Biology

1. P. Calder
2. C. Serhan
3. Carla C. C. R. de Carvalho
4. Undurti N. Das
5. B. Levy
6. M. Perretti
7. Maria-José Caramujo

In Physiology

1. P. Calder
2. C. Serhan
3. Dan Xiao
4. Weifeng Zhang
5. Carla C. C. R. de Carvalho
6. Haibin Xia
7. B. Levy
8. Q. Mao

Citations in the corpus

• Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale. (2009, background): “Table 2 lists pro-inflammatory actions of PGE 2 and 4-series LTs. AA metabolism is a long recognised target for anti-inflammatory agents and the efficacy of non-steroidal anti-inflammatory drugs, which act to inhibit cyclooxygenase activity, in inflammatory conditions indicates the importance of thi”
• n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. (2006, background): “formation of lipoxins (6, 7), which have been found to have”
• Role of neuroinflammation in neurodegeneration development (2023, background): “In addition, many enzymes (e.g., COX and LOX) involved in the generation of pro-inflammatory lipids are also important for the biosynthesis of SPMs.442 These kinds of anti-inflammatory drugs may interfere with beneficial effect of SPMs too.”
• PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation (2011, background): “pro-inflammatory leukotrienes and increased release of pro-resolution lipoxins in the course of the inflammatory reaction [12].”
• Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. (2018, background): “These antiinflammatories lower PMN amplitude (Ψ max ) but lengthen resolution interval (R i ) by impairing efferocytosis and/or uncoupling PGE 2 - and PGD 2 -dependent lipoxygenase expression (11, 92, 93).”
• Omega-6 fatty acids and inflammation. (2018, background): “For example, PGE2 has a number of pro-inflammatory effects including induction of fever, increase in vasodilation and vascular permeability and activation of pain perception as well as enhancement of pain caused by other agents.”
• Inflammation, a Key Event in Cancer Development (2006, background): “Prostaglandin E2 (8), transforming growth factor-h (9), and reactive oxygen and nitrogen intermediates (6) are among those molecules with a dual role in both promoting and suppressing inflammation.”
• Cellular and molecular mechanisms of skin wound healing (2024, positive): “One of the key triggers for this phenotype switch in wound macrophages towards pro-resolving functions may be their efferocytosis of spent neutrophils 116,117 , which also promotes the production and secretion of lipoxins by macrophages, promoting resolution of inflammation 118 .”