ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins

By Tala Bakheet, M. Frevel, Bryan R. G. Williams, W. Greer, Khalid S. A. Khabar. Nucleic Acids Res., 2001

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An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs (2013, background): “ARED [9,10] is a human AU-rich element-containing mRNA database.”
MiR-15a and miR-16-1 cluster functions in human leukemia (2008, background): “According to the number of motifs in the ARE stretch, the ARE-mRNAs can be clustered into five groups, containing five (cluster I), four (cluster II), three (cluster III), and two (cluster IV) pentameric repeats, whereas cluster V contains only one pentamer within the 13-bp ARE pattern as described ”
AU-rich elements and associated factors: are there unifying principles? (2006, background): “It has been estimated that 5–8% of human genes code for ARE-containing mRNAs; the corresponding proteins perform a variety of functions implicated in numerous transient biological processes (24,25).”
Diverse molecular functions of Hu proteins (2008, neutral): “Approximately 5-8 % of human genes code for mRNAs containing AREs [70,71].”
Involvement of microRNA in AU-rich element-mediated mRNA instability. (2005, background): “s ARE sequences from different mRNA can vary dra- d matically (Bakheet et al., 2001), with some containing t multiple AU-rich elements that allow for simultaneous n interaction with more than one miRNA.”