Diverse molecular functions of Hu proteins

By Melissa N. Hinman, H. Lou. Cellular and Molecular Life Sciences, 2008

595 citations recorded by the source corpus.

Abstract.Hu proteins are RNA-binding proteins involved in diverse biological processes. The neuronal members of the Hu family, HuB, HuC, and HuD play important roles in neuronal differentiation and plasticity, while the ubiquitously expressed family member, HuR, has numerous functions mostly related to cellular stress response. The pivotal roles of Hu proteins are dictated by their molecular functions affecting a large number of target genes. Hu proteins affect many post-transcriptional aspects of RNA metabolism, from splicing to translation. In this communication, we will focus on these molecular events and review our current understanding of how Hu proteins mediate them. In particular, emphasis will be put on the nuclear functions of these proteins, which were recently discovered. Three examples including calcitonin/calcitonin gene-related peptide, neurofibromatosis type 1, and Ikaros will be discussed in detail. In addition, an intriguing theme of antagonism between Hu proteins and other AU-rich sequence binding proteins will be discussed.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9fd838e9ae91ebfd8d5180b83468bc5d7f8a2ced

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Citations in the corpus

Integrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability (2011, background): “Prior to our study, across all four mammalian ELAV/Hu proteins there were a few known splicing and polyadenylation substrates (Hinman and Lou, 2008).”
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “HuR has a relatively well-characterized role in the cytoplasm, where it binds to mRNAs containing AREs and stabilizes, as well as affects translation of, a large number of mRNAs relevant to proliferation and apoptosis (Lopez de Silanes et al. 2005b; Hinman and Lou 2008).”
LincRNA-p21 suppresses target mRNA translation. (2012, background): “We hypothesized that HuR might stabilize lincRNA-p21, as HuR stabilizes many mRNAs (Hinman and Lou, 2008).”
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. (2011, background): “In the cytoplasm, Hu proteins can stabilize mRNAs by binding to AU-rich elements (AREs) within 3'UTRs (Brennan & Steitz, 2001), consistent with in vitro studies of HuR (Hinman & Lou, 2008, and references within).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “melanogaster embryonic lethal abnormal vision (ELAV) protein and have a broad function in stabilizing AU-rich element (ARE)-containing mRNAs in the cytoplasm (reviewed in Ref”