MiR-15a and miR-16-1 cluster functions in human leukemia

By George A. Calin, A. Cimmino, M. Fabbri, M. Ferracin, Sylwia E. Wojcik, M. Shimizu, Cristian Taccioli, N. Zanesi, R. Garzon, R. Aqeilan and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

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The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. (2010, background): “miR-15a/16-1 Control Proliferation in Mouse and Human B Cells To understand the mechanism by which the deletions lead to clonal B-lymphoproliferations, we investigated whether miR15a/16-1-deletions could affect proliferation of mouse B cells, as previously suggested for nonlymphoid cells (Bandi et a”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “Reintroduction of miR-15a/16-1, for example induces apoptosis in leukaemic MEG01 cells and inhibits tumour growth in vivo in a xenograft model (Calin et al, 2008), while silencing oncogenic miR-21 with antisense oligonucleotides generates a pro-apoptotic and anti-proliferative response in vitro in…”
MicroRNAs in development and disease. (2011, background): “In agreement, overexpression of miR-16 inhibits cell proliferation (373) and suppresses tumor growth after in vivo implantation (66).”
MicroRNAs in cancer: small molecules with a huge impact. (2009, background): “another oncogene of the BCL2 family of inhibitors of apoptosis.(37)”