A metagenome-wide association study of gut microbiota in type 2 diabetes

By J. Qin, Yingrui Li, Z. Cai, Shenghui Li, Jianfeng Zhu, Fan Zhang, Suisha Liang, Wenwei Zhang, Yuanlin Guan, Dongqian Shen and 46 more. Nature, 2012

6,195 citations recorded by the source corpus.

Subfields: General Health Professions, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b2d88e0e2274ad3d6807ace7aab25b30da1f7ef7

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Citations in the corpus

Liver inflammation and fibrosis. (2017, background): “Gut dysbiosis has been demonstrated in obesity (30, 31), metabolic syndrome (32), diabetes (33, 34), cardiovascular diseases, and NAFLD (35).”
GUT MICROBIOTA DYSBIOSIS IS LINKED TO HYPERTENSION (2015, result): “are linked to diabetes mellitus, obesity, and cardiac dysfunctions.(38) Our observations are consistent with these reports and”
Microbial strain-level population structure and genetic diversity from metagenomes (2017, positive): “StrainPhlAn allowed us to process >7 TB of sequencing data from the largest available metagenomic investigations (Qin et al. 2010, 2012; Human Microbiome Consortium 2012; Karlsson et al. 2013; Le Chatelier et al. 2013; Nielsen et al. 2014; Zeller et al. 2014; Obregon-Tito et al. 2015; Rampelli et…”
Role of the Microbiota in Immunity and inflammation (2014, background): “Significant changes to the commensal microbiota have been observed in T2D as well and, interestingly, are associated with a reduction in SCFA-producing strains of Clostridia and increases in E. coli (Karlsson et al., 2013; Qin et al., 2012).”
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, background): “muciniphilawere enriched in type 2 diabetic subjects (25).”
Gut Microbiota in Cardiovascular Health and Disease (2017, background): “Obesity has increased worldwide and is attributed to increased energy intake and reduced energy expenditure. by guest on A pril 1, 2017 http://circres.ahajournals.org/ D ow nloaded from Obesity increases the risk of multifactorial diseases such as T2DM.”